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Dr. Ina Patties

Computer-assisted Image-based Interventions - SonoRay

ina.patties@medizin.uni-leipzig.de

Background and Position

Ina Patties studied Biology at the Leipzig University where she graduated with a diploma in 2004. She finished her scientific dissertation in 2013. Thereby, her doctoral theses addressed the effects of ionizing radiation combined with epigenetic drugs on medulloblastoma cells. Her main research area focuses on experimental radiation therapy and clinical radiation biology including the effects of multimodal treatments on tumor and normal cells. In October 2016, she joined the SonoRay project which aims to enhance tumor therapy by combination of focused ultrasound with ionizing radiation.

Research Areas

Radiation biology and experimental radiation therapy
Tumor cell biology and cancer treatment

Publication List

2016
Patties I, Kortmann RD, Menzel F, Glasow A. Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs. J Exp Clin Cancer Res. 2016 Jun 17;35(1):94.

Prager I, Patties I, Himmelbach K, Kendzia E, Merz F, Müller K, Kortmann RD, Glasow A. Dose-dependent short- and long-term effects of ionizing irradiation on neural stem cells in murine hippocampal tissue cultures: neuroprotective potential of resveratrol. Brain and Behaviour 2016 Aug 12;6(10):e00548

2015
Patties I, Haagen J, Dörr W, Hildebrandt G, Glasow A. Late inflammatory and thrombotic changes in irradiated hearts of C57BL/6 wild-type and atherosclerosis-prone ApoE-deficient mice. Strahlenther. Onkol. 2015 (2):172-179.

2014
Patties I, Habelt B, Rosin B, Dörr W, Hildebrandt G, Glasow A. Late effects of local irradiation on the expression of inflammatory markers in the Arteria saphena of C57BL/6 wild-type and ApoE-knockout mice. Radiat Environ Biophys.2014 Mar;53(1):117-24.

2013
Patties I, Kortmann RD, Glasow A. Inhibitory effects of epigenetic modulators and differentiation inducers on human medulloblastoma cell lines. J Exp Clin Cancer Res 2013 (32):27

2012
Scholbach J, Schulz A, Westphal F, Egger D, Wege AK, Patties I, Köberle M, Sack U, Lange F. Comparison of Hematopoetic Stem Cells Derived from Fresh and Cryopreserved Whole Blood in the Generation of Huminized Mice. PLoS ONE 2012 7(10):e46772

2011
Jahns J, Anderegg U, Saalbach A, Rosin B, Patties I, Glasow A, Kamprad M, Scholz M, Hildebrandt G. Influence of low dose irradiation on differentiation, maturation and T-cell activation of human dendritic cells. Mutat Res. 2011 May 10; 709-710:32-9. Epub 2011 Mar 3.

2009
Patties I, Jahns J, Hildebrandt G, Kortmann RD, Glasow A. Additive effects of 5-aza-2′-deoxycytidine and irradiation on clonogenic survival of human medulloblastoma cell lines. Strahlenther Onkol. 2009 May;185(5):331-8. Epub 2009 May 15.

2006
Krauss V, Fassl A, Fiebig P, Patties I, Sass H. The evolution of the histone methyltransferase gene Su(var)3-9 in metazoans includes a fusion with and a re-fission from a functionally unrelated gene. BMC Evol Biol. 2006 Mar 2;6:18.

Published abstracts
2016
Patties I, Frisman M, Kendzia E, Menzel F, Gaunitz F, Kortmann RD, Glasow A. Radiosensitizing effect of 5-aza-2′-deoxycytidin in human glioblastoma cells. Klin Padiatr 2016 (6) 228-A4; 25th Annual Meeting of the Working Group “Experimental Neuro-Oncology”

Patties I, Frisman M, Kendzia E, Menzel F, Gaunitz F, Kortmann RD, Glasow A. The Chk1 inhibitor SAR-020105 abrogates the irradiation-induced G2 arrest and enhances the effect of irradiation on the clonogenic survival of human p53-mutant glioblastoma cells. Neuro-Oncology 2016 (18):iv26 P05.02, 12th EANO

2015
Prager I, Himmelbach K, Patties I, Merz, F, Müller K, Kortmann RD, Glasow A. Resveratrol erhöht die Anzahl Nestin-positiver neuraler Stammzellen in bestrahlten murinen Hippocampus Gewebekulturen, Strahlentherapie und Onkologie 2015 (1)- Zusatz, 21. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO); A-731-0007-00140

2014
Kaatzsch P, Eisenbruch K, Prager I, Patties I, Müller K, Kortmann RD, Glasow A. Untersuchung des Einflusses von Röntgenstrahlung auf die Neurogenese in murinen Hippocampus-Gewebekulturen. Proceedings des 23th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (23):85-87, ISSN 1432-864 X

Patties I, Kortmann RD, Glasow A. Enhancement of radiation effects by combined treatment with 5 aza-2’-deoxycytidine and differentiation-inducing or epigenetic drugs in human MB cells. Klin Padiatr 2014 (6) 226-A2; 23th Annual Meeting of the Working Group “Experimental Neuro-Oncology”,

Prager I, Patties I, Himmelbach K, Kallendrusch S, Oppermann H, Kortmann RD, Glasow A. Langzeiteffekte von Röntgenstrahlung in Kombination mit Resveratrol auf neurale Stammzellen in murinen Hippocampus-Gewebekulturen. Strahlentherapie und Onkologie 2014 (1)- Zusatz, 20. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO); A-656-0004-00212

Patties I, Kortmann RD, Glasow A. Resveratrol enhances radiation effects on clonogenic survival in human medulloblastoma cell lines. Neuro-Oncology 2014 (16):ii35 P03.07, 11th EANO

Prager I, Kaatzsch P, Himmelbach K, Patties I, Oppermann H, Merz F, Müller K, Kortmann RD, Glasow A. Time- and dose-dependent evaluation of irradiation-induced effects on murine hippocampal tissue cultures; partial radioprotection by resveratrol. Neuro-Oncology 2014 (16):ii34 P03.01, 11th EANO

Patties I, Kortmann RD, Glasow A. Resveratrol radiosensitize human medulloblastoma cell lines. Abstract Book 13th Leipzig Research Festival for Life Science 2014 (13): ISBN 978-3-9810760-9-7

Prager I, Kaatzsch P, Himmelbach K, Patties I, Oppermann H, Merz F, Müller K, Kortmann RD, Glasow A. Partial reversal of radiation-induced decline of neural progenitor cells by resveratol, Abstract Book 13th Leipzig Research Festival for Life Science 2014 (13): ISBN 978-3-9810760-9-7

2013
Müller K, Eisenbruch K, Patties I, Bechmann I, Kortmann RD, Glasow A. Untersuchung der Zytokinfreisetzung nach Röntgenbestrahlung von murinen Hippocampus-Gewebekulturen. Proceedings des 22. Symposiums für Experimentelle Strahlentherapie und Klinische Strahlenbiologie: 2013, Bd.22, ISSN 1432-864X

Glasow A, Kaatzsch P, Eisenbruch K, Patties I, Merz F, Kortmann RD, Müller K. Effect of ionizing irradiation on hippocampal cytokine release and neurogenesis in a murine (transgenic) tissue slice model. Klin Padiatr 2013 (6) 225-A11; 22th Annual Meeting of the Working Group “Experimental Neuro-Oncology”

Glasow A, Kaatzsch P, Prager I, Müller K, Himmelbach K, Patties I, Kortmann RD. Influence of radiation dose and fractionation on hippocampal microenvironment and neurogenesis – preliminary results using a (transgenic) murine tissue slice model. Abstract Book 12th Leipzig Research Festival for Life Science 2013 (12): 264, ISBN 978-3-9810760-9-7

Patties I, Kortmann RD, Glasow A. Treatment of human medulloblastoma cell lines with combinations of %-aza-2’deoxycytidine and differentiation-inducing or epigenetic drugs. Abstract Book 12th Leipzig Research Festival for Life Science 2013 (12): 348, ISBN 978-3-9810760-9-7

2012
Patties I, Kortmann RD, Glasow A. Einfluss von 5-aza-2’deoxycytidin und Bestrahlung auf das klonogene Überleben und die Stammzellpopulation in humanen Medulloblastomzellen. Proceedings des 21th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (21):125-29, ISSN 1432-864 X Travel award winner

Patties I, Kortmann RD, Glasow A. Combinatorial effects of Resveratrol, 5_aza-2’deoxycytidine, and irradiation on clonogenic survival and stem cell population in human Medulloblastoma cell lines. Klin Padiatr 2012 (6) 224-A12; 21th Annual Meeting of the Working Group “Experimental Neuro-Oncology”

Patties I, Kortmann RD, Glasow A. Effects of Resveratrol and 5 aza 2’-deoxycytidine on double-strand break repair and clonogenic survival after irradiation of human medulloblastoma cell lines. Pediatr Blood Cancer 2012; Dec 6 (59):1081; SIOP 2012

2011
Paape D, Manda K, Glasow A, Patties I, Hildebrandt G. Untersuchung der Expression inflammatorischer und thrombotischer myokardialer Marker nach moderater und niederer Strahlenexposition. Proceedings des 20th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (20):137-39, ISSN 1432-864 X

Patties I, Rosin B, Hildebrandt G, Glasow A. Inflammatorische Veränderungen der Arteria saphena (A. saphena) nach Bestrahlung in Mäusen. Proceedings des 20th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (20):163-65, ISSN 1432-864 X

Patties I, Kortmann RD, Glasow A. Veränderungen der CD15+- und CD133+- Subpopulation von humanen Medulloblastomzelllinien nach Behandlung mit ionisierender Strahlung und 5-aza-2’-deoxycytidin. Abstract Book 10th Leipzig Research Festival for Life Science 2011 (10): 351, ISBN 978-3-9810760-7-3

2010
Patties I, Jahns J, Kortmann RD, Hildebrandt G, Glasow A. Untersuchungen neuer Behandlungskonzepte der Radio-Chemotherapie an humanen Medulloblastom- Zelllinien. Abstract Book 8th Leipzig Research Festival for Life Science 2010 (8): 256, ISBN 3-9810760-5-2

Patties I, Jahns J, Kortmann RD, Hildebrandt G, Glasow A. Wirkung variierter Kombinationen von 5’Aza-2’Deoxycytidin und Bestrahlung auf das klonogene Überleben von humanen Medulloblastomzelllinien. Proceedings des 19th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (19):46-50, ISSN 1432-864 X

2008
Patties I, Glasow A, Jahns J, Kortmann RD, Hildebrandt G. Einfluss von 5‘Aza-2‘Deoxycytidin auf die Strahlensensitivität von humanen Medulloblastomzelllinien. Proceedings des 17th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (17):138-142, ISSN 1432-864 X

Patties I, Glasow A, Jahns J, Hildebrandt G, Kortmann RD. Einfluss von 5‘Aza-2‘Deoxycytidin auf die Strahlensensitivität von humanen Medulloblastomzelllinien Strahlenther Onkol 2008;184 (Sondernr 1): 1–165 DEGRO-ÖGRO

Full text publications

2016
Patties I, Kortmann RD, Menzel F, Glasow A. Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs. J Exp Clin Cancer Res. 2016 Jun 17;35(1):94.

Prager I, Patties I, Himmelbach K, Kendzia E, Merz F, Müller K, Kortmann RD, Glasow A. Dose-dependent short- and long-term effects of ionizing irradiation on neural stem cells in murine hippocampal tissue cultures: neuroprotective potential of resveratrol. Brain and Behaviour 2016 Aug 12;6(10):e00548

2015
Patties I, Haagen J, Dörr W, Hildebrandt G, Glasow A. Late inflammatory and thrombotic changes in irradiated hearts of C57BL/6 wild-type and atherosclerosis-prone ApoE-deficient mice. Strahlenther. Onkol. 2015 (2):172-179.

2014
Patties I, Habelt B, Rosin B, Dörr W, Hildebrandt G, Glasow A. Late effects of local irradiation on the expression of inflammatory markers in the Arteria saphena of C57BL/6 wild-type and ApoE-knockout mice. Radiat Environ Biophys.2014 Mar;53(1):117-24.

2013
Patties I, Kortmann RD, Glasow A. Inhibitory effects of epigenetic modulators and differentiation inducers on human medulloblastoma cell lines. J Exp Clin Cancer Res 2013 (32):27

2012
Scholbach J, Schulz A, Westphal F, Egger D, Wege AK, Patties I, Köberle M, Sack U, Lange F. Comparison of Hematopoetic Stem Cells Derived from Fresh and Cryopreserved Whole Blood in the Generation of Huminized Mice. PLoS ONE 2012 7(10):e46772

2011
Jahns J, Anderegg U, Saalbach A, Rosin B, Patties I, Glasow A, Kamprad M, Scholz M, Hildebrandt G. Influence of low dose irradiation on differentiation, maturation and T-cell activation of human dendritic cells. Mutat Res. 2011 May 10; 709-710:32-9. Epub 2011 Mar 3.

2009
Patties I, Jahns J, Hildebrandt G, Kortmann RD, Glasow A. Additive effects of 5-aza-2′-deoxycytidine and irradiation on clonogenic survival of human medulloblastoma cell lines. Strahlenther Onkol. 2009 May;185(5):331-8. Epub 2009 May 15.

2006
Krauss V, Fassl A, Fiebig P, Patties I, Sass H. The evolution of the histone methyltransferase gene Su(var)3-9 in metazoans includes a fusion with and a re-fission from a functionally unrelated gene. BMC Evol Biol. 2006 Mar 2;6:18.

Published abstracts
2016
Patties I, Frisman M, Kendzia E, Menzel F, Gaunitz F, Kortmann RD, Glasow A. Radiosensitizing effect of 5-aza-2′-deoxycytidin in human glioblastoma cells. Klin Padiatr 2016 (6) 228-A4; 25th Annual Meeting of the Working Group “Experimental Neuro-Oncology”

Patties I, Frisman M, Kendzia E, Menzel F, Gaunitz F, Kortmann RD, Glasow A. The Chk1 inhibitor SAR-020105 abrogates the irradiation-induced G2 arrest and enhances the effect of irradiation on the clonogenic survival of human p53-mutant glioblastoma cells. Neuro-Oncology 2016 (18):iv26 P05.02, 12th EANO

2015
Prager I, Himmelbach K, Patties I, Merz, F, Müller K, Kortmann RD, Glasow A. Resveratrol erhöht die Anzahl Nestin-positiver neuraler Stammzellen in bestrahlten murinen Hippocampus Gewebekulturen, Strahlentherapie und Onkologie 2015 (1)- Zusatz, 21. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO); A-731-0007-00140

2014
Kaatzsch P, Eisenbruch K, Prager I, Patties I, Müller K, Kortmann RD, Glasow A. Untersuchung des Einflusses von Röntgenstrahlung auf die Neurogenese in murinen Hippocampus-Gewebekulturen. Proceedings des 23th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (23):85-87, ISSN 1432-864 X

Patties I, Kortmann RD, Glasow A. Enhancement of radiation effects by combined treatment with 5 aza-2’-deoxycytidine and differentiation-inducing or epigenetic drugs in human MB cells. Klin Padiatr 2014 (6) 226-A2; 23th Annual Meeting of the Working Group “Experimental Neuro-Oncology”,

Prager I, Patties I, Himmelbach K, Kallendrusch S, Oppermann H, Kortmann RD, Glasow A. Langzeiteffekte von Röntgenstrahlung in Kombination mit Resveratrol auf neurale Stammzellen in murinen Hippocampus-Gewebekulturen. Strahlentherapie und Onkologie 2014 (1)- Zusatz, 20. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO); A-656-0004-00212

Patties I, Kortmann RD, Glasow A. Resveratrol enhances radiation effects on clonogenic survival in human medulloblastoma cell lines. Neuro-Oncology 2014 (16):ii35 P03.07, 11th EANO

Prager I, Kaatzsch P, Himmelbach K, Patties I, Oppermann H, Merz F, Müller K, Kortmann RD, Glasow A. Time- and dose-dependent evaluation of irradiation-induced effects on murine hippocampal tissue cultures; partial radioprotection by resveratrol. Neuro-Oncology 2014 (16):ii34 P03.01, 11th EANO

Patties I, Kortmann RD, Glasow A. Resveratrol radiosensitize human medulloblastoma cell lines. Abstract Book 13th Leipzig Research Festival for Life Science 2014 (13): ISBN 978-3-9810760-9-7

Prager I, Kaatzsch P, Himmelbach K, Patties I, Oppermann H, Merz F, Müller K, Kortmann RD, Glasow A. Partial reversal of radiation-induced decline of neural progenitor cells by resveratol, Abstract Book 13th Leipzig Research Festival for Life Science 2014 (13): ISBN 978-3-9810760-9-7

2013
Müller K, Eisenbruch K, Patties I, Bechmann I, Kortmann RD, Glasow A. Untersuchung der Zytokinfreisetzung nach Röntgenbestrahlung von murinen Hippocampus-Gewebekulturen. Proceedings des 22. Symposiums für Experimentelle Strahlentherapie und Klinische Strahlenbiologie: 2013, Bd.22, ISSN 1432-864X

Glasow A, Kaatzsch P, Eisenbruch K, Patties I, Merz F, Kortmann RD, Müller K. Effect of ionizing irradiation on hippocampal cytokine release and neurogenesis in a murine (transgenic) tissue slice model. Klin Padiatr 2013 (6) 225-A11; 22th Annual Meeting of the Working Group “Experimental Neuro-Oncology”

Glasow A, Kaatzsch P, Prager I, Müller K, Himmelbach K, Patties I, Kortmann RD. Influence of radiation dose and fractionation on hippocampal microenvironment and neurogenesis – preliminary results using a (transgenic) murine tissue slice model. Abstract Book 12th Leipzig Research Festival for Life Science 2013 (12): 264, ISBN 978-3-9810760-9-7

Patties I, Kortmann RD, Glasow A. Treatment of human medulloblastoma cell lines with combinations of %-aza-2’deoxycytidine and differentiation-inducing or epigenetic drugs. Abstract Book 12th Leipzig Research Festival for Life Science 2013 (12): 348, ISBN 978-3-9810760-9-7

2012
Patties I, Kortmann RD, Glasow A. Einfluss von 5-aza-2’deoxycytidin und Bestrahlung auf das klonogene Überleben und die Stammzellpopulation in humanen Medulloblastomzellen. Proceedings des 21th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (21):125-29, ISSN 1432-864 X Travel award winner

Patties I, Kortmann RD, Glasow A. Combinatorial effects of Resveratrol, 5_aza-2’deoxycytidine, and irradiation on clonogenic survival and stem cell population in human Medulloblastoma cell lines. Klin Padiatr 2012 (6) 224-A12; 21th Annual Meeting of the Working Group “Experimental Neuro-Oncology”

Patties I, Kortmann RD, Glasow A. Effects of Resveratrol and 5 aza 2’-deoxycytidine on double-strand break repair and clonogenic survival after irradiation of human medulloblastoma cell lines. Pediatr Blood Cancer 2012; Dec 6 (59):1081; SIOP 2012

2011
Paape D, Manda K, Glasow A, Patties I, Hildebrandt G. Untersuchung der Expression inflammatorischer und thrombotischer myokardialer Marker nach moderater und niederer Strahlenexposition. Proceedings des 20th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (20):137-39, ISSN 1432-864 X

Patties I, Rosin B, Hildebrandt G, Glasow A. Inflammatorische Veränderungen der Arteria saphena (A. saphena) nach Bestrahlung in Mäusen. Proceedings des 20th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (20):163-65, ISSN 1432-864 X

Patties I, Kortmann RD, Glasow A. Veränderungen der CD15+- und CD133+- Subpopulation von humanen Medulloblastomzelllinien nach Behandlung mit ionisierender Strahlung und 5-aza-2’-deoxycytidin. Abstract Book 10th Leipzig Research Festival for Life Science 2011 (10): 351, ISBN 978-3-9810760-7-3

2010
Patties I, Jahns J, Kortmann RD, Hildebrandt G, Glasow A. Untersuchungen neuer Behandlungskonzepte der Radio-Chemotherapie an humanen Medulloblastom- Zelllinien. Abstract Book 8th Leipzig Research Festival for Life Science 2010 (8): 256, ISBN 3-9810760-5-2

Patties I, Jahns J, Kortmann RD, Hildebrandt G, Glasow A. Wirkung variierter Kombinationen von 5’Aza-2’Deoxycytidin und Bestrahlung auf das klonogene Überleben von humanen Medulloblastomzelllinien. Proceedings des 19th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (19):46-50, ISSN 1432-864 X

2008
Patties I, Glasow A, Jahns J, Kortmann RD, Hildebrandt G. Einfluss von 5‘Aza-2‘Deoxycytidin auf die Strahlensensitivität von humanen Medulloblastomzelllinien. Proceedings des 17th Symposiums Experimentelle Strahlentherapie und Klinische Strahlenbiologie (17):138-142, ISSN 1432-864 X

Patties I, Glasow A, Jahns J, Hildebrandt G, Kortmann RD. Einfluss von 5‘Aza-2‘Deoxycytidin auf die Strahlensensitivität von humanen Medulloblastomzelllinien Strahlenther Onkol 2008;184 (Sondernr 1): 1–165 DEGRO-ÖGRO

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