The annual International Conference on Biomedical and Health Informatics (BHI) by the Institute of Electrical and Electronics Engineers (IEEE) and Engineering in Medicine and Biology Society (EMBS) in its 2021 edition was held online jointly with the International Conference on Wearable and Implantable Body Sensor Networks (BSN). ICCAS representation at the joint conference was multifaceted. Prof. Andreas Melzer was part of the regulatory panel that addressed the issues on medical device legislation. Specifically, he outlined the legal aspects to software with artificial intelligence classified as a medical device. In addition, recent technological results from our research field Biomedical Data Analysis were presented during the Special Session “Mobile Digital Solutions in Patient Care – Challenges and Opportunities” organized by Prof. Ivanova. The team around the Post-Stroke Manager project was represented with three further contributions.