Radiation therapy is one of the main modalities of treatment for cancer patients in addition to conventional surgery and chemotherapy. Focused ultrasound (FUS) plays an increasing role in medical applications because of its thermal and mechanical effects on tissue, cells and bio-molecules, expanding its traditional applications from imaging and diagnostics to therapeutics.
While hyperthermia and ablation with HIFU (Ter Haar 2001) are better established therapeutic methods, there is very significant research interest in ultrasound combined therapeutic approaches. Increased radiation sensitivity of tumor cells by high-intensity focused ultrasound exposure has already been demonstrated experimentally. Despite the potential of these studies, previous experiments were carried out only in vitro and on selected tumor cells. There is therefore a great need to carry out further systematic in vitro and, based on this, in vivo experiments in a suitable model to validate the effects of FUS.