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This year’s online congress of the Society for Computer Assisted Radiology and Surgery (CARS) takes place from June 21 to 25. ICCAS’ participation in the scientific program of the annual international meeting has become almost a tradition and the 2021 virtual edition of the congress is no exception in this regard. On the opening day, Prof. Thomas Neumuth chaired the session on image-guided interventions. Dr. Claire Chalopin – project leader of the Intraoperative Multimodal Imaging research group – further contributed with two lectures on the use of Intraoperative 3D Ultrasound Imaging in brain tumor surgical procedures. Additionally, Richard Bieck – Senior Scientist and Quality Management Representative at ICCAS – is involved in the workshop on the international initiative IHE Surgery and recognized standards such as DICOM dedicated to improving the way computer systems exchange information in the healthcare sector.