The annual meeting of the Radiological Society of North America (RSNA) was held Nov. 28-Dec. 2 in Chicago as a hybrid event. More than 19,000 attendees registered for the conference, and another 4,000 participated virtually. The high-profile program included 2,000 scientific presentations, 1,500 educational exhibits and more than 300 educational courses. Cutting-edge radiology innovations from more than 500 exhibitors complemented the conference experience. As in previous years, ICCAS also presented its own research results in the field of radiology. Andreas Melzer reported on-site on the promising application of MRI-guided focused ultrasound to sensitize prostate cancer to radiotherapy.