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Weitere Projekte

headline-markerMOMENTUM

Mobile Medical Technology for Integrated Emergency Care and Accident Medicine

Sponsors: Federal Ministry of Education and Research (BMBF),

In the MOMENTUM project, medical technology is being developed that can be used not only in the hospital (eg in the trauma room, operating theater, intensive care unit), but also in preclinical care at the scene of the accident and in the ambulance. … (more informations)

headline-markerCOMPASS

Comprehensive Surgical Landscape Guidance System for Immersive Assistance in Minimally-invasive and Microscopic Interventions

Sponsors: Federal Ministry of Education and Research (BMBF),

The surgical navigation process in minimally-invasive endoscopic surgery is time- and resource- constrained and conventional navigation assistance technology is reduced to a passive-supportive role. In the project COMPASS, a new technology for immersive assistance in minimally-invasive and microscopic interventions is developed to convert navigation systems into fully-acknowledged surgical actors. … (more informations)

headline-markerENSEMBLE

Development of a scalable and magnetic resonance (MR)-compatible blood circulation model

Sponsors: Federal Ministry for Economic Affairs and Energy (BMWi),

The project ENSEMBLE encompasses the development of a scalable and magnetic resonance-compatible cardiovascular system model. This closed-loop system shall be available as a self-contained trainings module, allowing the practicing of multiple surgical procedures, e.g. catheter-based operations. Using the developed model, future surgeons will be able to simulate realistic operations, so they can develop and expand their cognitive and motoric skills during the course of multiple practice sessions.

In order to present a trainings model, which is as realistic as possible, a pump, an artificial blood vessel tree and a blood-like fluid will be combined with auxiliary components. The developed system will allow for a simulated blood circulation, so that it will be possible to create an artificial operating situation, which immerses the trainee as best as possible. The deployed pump will be able to measure pressure, recognize changes in the pressure curve and adjust its regulation parameters automatically. Furthermore, it will be small, adaptable and powerful enough to drive the fluid inside of the circulatory system. This branched system will be composed of single arteries, capillaries and veins with additional valves, whose layout will be developed by an automatic segmentation algorithm. The permeability, thickness, elasticity and diameters of the artificial vessels will be comparable to their real counterparts. That way, the model shall provide a realistic reaction, when surgeons practice cuts or sutures with their instruments on it. The blood-like fluid, that the model is filled with, will possess a viscosity which shall be displayable to the user as well as adjustable to use-case-specific requirements.

headline-markerPAPA-ARTIS

PAPA-ARTIS – Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with ‘Minimally-Invasive Segmental Artery Coil-Embolization’: A Randomized Controlled Multicentre Trial; Subproject: Patient-based individual modeling of Paraspinal Collateral Network Perfusion after Segmental Artery Occlusion (PimPaP)

Sponsors: European Union funding for Research and Innovation: Horizon 2020,

The initial goal is to establish a general understanding of the coiling patterns and their impact on the convalescence of spinal perfusion and the clinical outcome. Initially, an extensible patient model needs to be developed including multi-modal imaging & procedure parameters, e. g. blood pressure, heart rhythm, CVP, rMAP as well as anatomical parameters, such as Crawford classification, calcification status and artery kinking. … (more informations)

headline-markerProDial

Patient-Reported Outcome, Biodata and Process Data to Evaluate Dialysis Tolerability

Sponsors: ERAPerMed,

Haemodialysis treatment affects only 0.1% of the total population. However, this complex, long-term and chronic procedure requires 5 to 10% of the total health care costs in industrialized countries. Although the treatment ensures life-sustaining detoxification, it does not prevent the 5 to 10 times higher mortality of those affected patients with end-stage renal disease compared to the general population.

Nowadays, quality and process control of hemodialysis treatment is based on a general evaluation of biochemical and procedural measures, which does not really influence the individual patient’s outcome in terms of mortality and dialysis tolerance. For this reason, the ProDial project aims to develop an individual analysis of the dialysis treatment and a personalized data generation and handling scheme. For this purpose, time-synchronous data of different dialysis aspects will be collected and evaluated. This includes patient and therapy characteristics, biomedical real-time feedback, process information and patient reported outcomes. Innovative and anonymized data collection methods, including the integration of portable personal devices and sensors, will ensure integrated, searchable and personalized data storage.

Novel mechanisms for finding significant correlations between the referenced data categories should enable the development of personalized real-time dialysis treatment procedures in the long term. These data-based algorithms can then be integrated into modern and intelligent dialysis centers and, thus, facilitate a truly personalized real-time treatment. Such a treatment would respond immediately to the individual co-morbidity and tolerability behavior of the patient.

Link to project page

headline-markerLYSiS

Innovative imaging for tissue differentiation in minimally invasive surgery - subproject: Investigation of computer-assisted methods for automatic characterization, recognition and presentation of tissue from intraoperative hyperspectral imaging data

Sponsors: Federal Ministry of Education and Research (BMBF),

The aim is to develop a new laparoscopic imaging system and supporting non-invasive intraoperative measures to increase the identification and classification of risk structures and lesions for visceral, transplantation, thoracic and vascular surgery based on the latest high-resolution HSI technology. … (more informations)

headline-markerSORLIC

Development of an assistance system for the intraoperative planning of reconstructive procedures

Sponsors: Federal Ministry for Economic Affairs and Energy (BMWi), ZIM – Central Innovation Programe for Small and Medium-sized Enterprises,

Tumor diseases, traumatic damage and malformations often cause defects of body integrity, which makes plastic-reconstructive surgery necessary. Extensive defects require, among other things, the transfer of distant free flaps. Until now, the different pre- and intraoperative images have been analyzed and interpreted visually by the surgeon. However, there is no assistance system on the market that supports the intraoperative planning of reconstructive surgeries.
The SORLIC project aims at the development of such a mobile system, which will consist of a mobile cart, a measurement system, image processing functionalities for the automatic interpretation of image data, and a user interface for controlling the system and for generating medical documentation. It shall automatically recognize the perforator vessels and the supplied regions by means of imaging and propose a donor flap placement. This information will be projected onto the patient to support the surgeon in the decision making process.

headline-markerMSI Endoscope

Endoscopic Multispectral Imaging with Real Time Pulse Oximetry System for Medical Applications

Sponsors: KARL STORZ SE & Co. KG,

Aim of this project is to develop a real time pulse oximetry system based on endoscopic multispectral imaging. Relevant medical applications will be determined and preclinically evaluated.

headline-markerHSI – Laparo/Endoscopy

Automated tissue recognition and visualisation with laparoscopic hyperspectral imaging.

Sponsors: KARL STORZ SE & Co. KG,

The project aims to acquire and analyse hyperspectral data with a laparoscopic HSI-system in the clinical context. Furthermore, methods for the automated classification and visualisation of tissue with hyperspectral data will be developed and implemented.

headline-markerIMPACT

KMU-innovativ-joint project: IMPACT – Mobile system for emergency medical diagnosis and monitoring of the pneumothorax; Subproject: Data integration and modeling

Sponsors: Federal Ministry of Education and Research (BMBF),

The goal of this project is the development of a mobile system for lung function diagnostics in emergency situations. Based on electrical impedance tomography (EIT), changes of electrical properties in the lung are measured using an easily applicable electrode belt. This allows for a three-dimensional imaging and functional analysis to assess ventilation status. … (more informations)

headline-markerEMU

Ventilation System with Electrical Impedance Imaging to monitor patient condition and to optimally ventilate the patient; Development of analysis algorithms and pre-clinical evaluation of the novel multi-modal ventilation system

Sponsors: Federal Ministry for Economic Affairs and Energy (BMWi),

A multi-modal ventilation system combined with an EIT measurement device will be developed to be used for temporary monitoring and automated ventilation of the patient. Vital parameters such as lung activity and lung volume will be measured. Additionally, a thorax belt integrates EIT-based imaging of the lung. … (more informations)

headline-markerSONO-RAY (META-ZIK)

Tumor Therapy Combined by MR-Guided Focused Ultrasound and Radiation Therapy

Sponsors: Federal Ministry of Education and Research (BMBF),

Radiation therapy is one of the main modalities of treatment for cancer patients in addition to conventional surgery and chemotherapy. Focused ultrasound (FUS) plays an increasing role in medical applications because of its thermal and mechanical effects on tissue, cells and bio-molecules, expanding its traditional applications from imaging and diagnostics to therapeutics. … (more informations)

headline-markerCURE-OP

Joint project: Oncological therapy platform for combined ultrasound radiation therapy | Subproject: Development and integration of a robot system for simultaneous ultrasound radiotherapy

Sponsors: Federal Ministry of Education and Research (BMBF),

The aim of CURE-OP is to develop the first commercially available high intensity focused ultrasound (HIFU) platform specifically designed for combinational cancer therapy. Today, the most common treatment options to cure cancer are surgery, radiation therapy (RT), chemotherapy and targeted therapy including immunotherapy. The approach followed in the CURE-OP project is not to replace any of those options, but to use focused ultrasound to enhance their effectiveness, in this case, the outcome of radiotherapy. … (more informations)

headline-markerImaging Robotics

Sponsors:

Image-guided medical interventions gain more and more clinical acceptance. The imaging via ultrasound, X-ray computed tomogra­phy or magnetic resonance tomography allows minimal- and non-invasive pro­cedures such as biopsies, thermal ablation, and emboli­zation. Image guidance leads to smaller incisions and thus re­duces inflammation and hospitalization. … (more informations)

headline-markerMRg-LIFUP

NEURO-MODULATION USING MRI-GUIDED LIGHT INTENSITY FOCUSED ULTRASOUND

Sponsors:

In cooperation with the Max Planck Institute for Cognitive and Neurosciences and the Fraunhofer Institute for Biomedical Engineering (IBMT) in St. Ingbert, the possibilities of the application of Focused Ultrasound (FUS) for neuromodulation and neurostimulation are investigated. … (more informations)

headline-markerMR-Biopsy

MR Safe Flexible Biopsy Forceps for Minimally Invasive Tissue Sampling; Subproject: Research of Novel MRI and X-Ray Markers and Development of a Novel MRI-Guided Intervention Technique for Biopsy (MR Biopsy)

Sponsors: Federal Ministry of Education and Research (BMBF),

The goal of the joint project ‘MR-Biopsy’ is to research a worldwide first MR safe flexible biopsy forceps. This should improve the minimally invasive and image-guided removal of tissue samples without the previous high X-ray and contrast agent exposure. … (more informations)

headline-markerMR-Stents

MR-Guided Stent-Implantation

Sponsors: Federal Ministry of Education and Research (BMBF),

Goal of the joint project MR-Stents is the development of a Magnetic Resonance (MR)-guided stent implantation. MR imaging obviates the exposure to radiation and contrast media and enables an increased differentiation of the heart, blood flow analysis, and a 3D display of the heart – enhancing the stent implantation procedure. … (more informations)

headline-markerMR-Thrombosis

MR-guided minimally-invasive diagnostics and therapy of thrombosis – MR-Thrombosis-Theranostics

Sponsors: Federal Ministry of Education and Research (BMBF),

The goal of the joint project MR-Thrombosis-Theranostics is the research and development of a Magnetic Resonance (MR)–guided diagnosis and minimally-invasive therapy of thromboses. MR-guidance overcomes the aforementioned disadvantages of X-Ray fluoroscopy and adds high soft tissue contrast. … (more informations)

headline-markerMoVE

Modular Validation Environment for Medical Device Networks

Sponsors: Federal Ministry of Education and Research (BMBF),

Background:
The integration and networking of medical equipment has become an indispensable component of modern operating theatres. At present, the market is characterized by closed solutions, which are regulatorily approved as monolithic settings. The aim of the project is therefore to develop methods that support the development of openly integrated medical devices as well as the approval process by means of a test environment. The project aims to ease the access of SMEs to the market with innovative technologies.

Material & Methods
A simulation environment, including communication infra-structure, simulated medical devices and test scenarios, is being developed. The test platform will verify the networking of medical devices and software components and validate the communication regarding conformity with the communication standards, appropriate message and communication patterns, and timing aspects.
Realistic, scenario-based simulations of an OR setup and its communication are implemented by a simulation engine and emulators of medical devices. Based on an integration with the IEEE 11073 SDC standards family, manufacturers can test their products against the virtual infrastructure early on in the development process.
In the frame of the project, ICCAS is responsible for the automated generation of realistic test scenarios from recordings of real interventions. Methods are developed that use already well-developed stochastic workflow modeling approaches to sample possible intervention courses and orchestrate the states and parameters of the emulated devices based on the estimated surgeon’s behavior. To that end, a simulation engine is implemented, which reads formal descriptions of user and device behavior. A network of sampling components of various types, including Hidden Markov Models, Random Forests, and empirical distributions, is set up and is frequently updated upon the run of a scenario to generate realistic measurements, device parameter configurations, and remote procedure calls for the device under test.

Results
In December 2019, we were able to present the results of the project in presentations and several demo stations. In a first step, the basic interoperability of medical devices using the IEEE11073-SDC standard family was checked. In a second step, complete surgical interventions with a variety of real and simulated medical devices could be performed using a complex simulation framework. In particular, the behavior of the device under test and the network interface can be checked. In the last demo station, the individual components were brought together, and the corresponding result reports were generated based on the results of the test runs. The feedback from the 50 participants in the final presentation on the results shown was consistently positive.

headline-markerDPM

Digitales Patient- and Process Model

Sponsors: Federal Ministry of Education and Research (BMBF),

In the project, information theoretical concepts for the formal description and modelling of patient data and surgical decision-making processes are developed. Patient models link and analyze all data relevant for surgery and therapy planning and thus enable an all-round representation of the patient and his diseased organ. Decision models describe the decision-making processes. … (more informations)

headline-markerAutoSON

Automatic navigated intraoperative ultrasound imaging for brain tumor removal | Subproject: Development of innovative automatic functionalities within a research platform, scientific evaluation of the algorithms and clinical evaluation of the AutoSon system

Sponsors: Federal Ministry for Economic Affairs and Energy (BMWi),

Goal of the project AutoSon is the development of a networked assistance system to support neurosurgical interventions. The AutoSon system includes an expanded neurosurgical navigation system inter-connected with a research platform. The AutoSon system will interact through opened interfaces during all phases of the clinical workflow: the planning, execution and documentation of the operation. … (more informations)

headline-markerEU-MFH

European Modular Field Hospital

Sponsors: European Commission,

The aim of this international project is to substantially improve medical care during European disaster relief missions. The various EU Member States are contributing their specific expertise in order to develop a mobile emergency field hospital which can be quickly set up and used to treat a large number of patients from first response to hospital care. … (more informations)